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A study showed that PYY null mice developed marked obesity that may be reversed by exogenous PYY treatment, suggesting that this hormone plays a role not only in postprandial early satiety but also in long-term, by regulating energy balance through unknown mechanism.27 Glucagon like peptide-1 (GLP-1) and oxyntomodulin (OXM) GLP-1 and OXM are products of the preproglucagon gene, which is expressed in the CNS, in the L-cells of the small intestine, and in pancreas
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Genetic predispositions in these receptors may help explain individual variation in treatment response, which should be interpreted alongside clinical assessment by your qualified healthcare provider
10.1089/ars.2014.6025 15 FarrisW.MansourianS.ChangY.LindsleyL.EckmanE
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